SATB1 in Malignant T Cells

Research output: Contribution to journalArticle


title = "SATB1 in Malignant T Cells",
abstract = "Deficient expression of SATB1 hampers thymocyte development and results in inept T-cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides, the most frequent variant of cutaneous T-cell lymphoma. Here, we report on a disease stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. STAT5 inhibited SATB1 expression through induction of microRNA-155. Decreased SATB1 expression triggered enhanced expression of IL-5 and IL-9 (but not IL-6 and IL-32), whereas increased SATB1 expression had the opposite effect, indicating that the microRNA-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells. In accordance, inhibition of STAT5 and its upstream activator JAK3 triggered increased SATB1 expression and a concomitant suppression of IL-5 and IL-9 expression in malignant T cells. In conclusion, we provide a mechanistic link between the proto-oncogenic JAK3/STAT5/microRNA-155 pathway, SATB1, and cytokines linked to CTCL severity and progression, indicating that SATB1 dysregulation is involved in cutaneous T-cell lymphoma pathogenesis.",
author = "Simon Fredholm and Andreas Willerslev-Olsen and {\"O}zcan Met and Linda Kubat and Maria Gluud and Mathiasen, {Sarah L.} and Christina Friese and Edda Bl{\"u}mel and Petersen, {David L.} and Tengpeng Hu and Claudia Nastasi and Lindahl, {Lise M.} and Buus, {Terkild B.} and Thorbj{\o}rn Krejsgaard and Wasik, {Mariusz A.} and Kopp, {Katharina L.} and Koralov, {Sergei B.} and Persson, {Jenny L.} and Bonefeld, {Charlotte M.} and Carsten Geisler and Anders Woetmann and Lars Iversen and Becker, {J{\"u}rgen C.} and Niels {\O}dum",
year = "2018",
doi = "10.1016/j.jid.2018.03.1526",
language = "English",
volume = "138",
pages = "1805--1815",
journal = "Advances in biology of skin",
issn = "1523-1747",
publisher = "Nature Publishing Group",
number = "8",