Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: We studied mutations in MODY1-4 genes, the presence of GAD antibodies, and HLA DQB1 risk genotypes in 66 Swedish women with GDM and a family history of diabetes. An oral glucose tolerance test was repeated in 46 women at 1 year postpartum. RESULTS: There was no increase in type 1 diabetes-associated HLA-DQB1 alleles or GAD antibodies when compared with a group of type 2 diabetic patients (n = 82) or healthy control subjects (n = 86). Mutations in known MODY genes were identified in 3 of the 66 subjects (1 MODY2, 1 MODY3, and 1 MODY4). Of the 46 GDM subjects, 2 had diabetes (4%) and 17 had impaired glucose tolerance (IGT) (37%) at 1 year postpartum. Of the two subjects who developed manifest diabetes, one carried a MODY3 mutation (A203H in the hepatocyte nuclear factor-1alpha gene). There was no increase in high-risk HLA alleles or GAD antibodies in the women who had manifest diabetes or IGT at 1 year postpartum. CONCLUSIONS: MODY mutations but not autoimmunity contribute to GDM in Swedish women with a family history of diabetes and increase the risk of subsequent diabetes.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • Diabetes Mellitus Non-Insulin-Dependent : genetics, Diabetes Gestational : genetics : immunology, Female, Support Non-U.S. Gov't, Sweden, Risk Assessment, Pregnancy, Patient Selection, Mutation, Middle Age, Human, HLA Antigens : genetics, HLA-DQ Antigens : genetics, Genotype, Glucose Intolerance : genetics : immunology, Adult, Diabetes Mellitus Insulin-Dependent : genetics : immunology
Original languageEnglish
Pages (from-to)68-71
JournalDiabetes Care
Volume25
Issue number1
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Endocrinology (013241500), Department of Obstetrics and Gynaecology (Lund) (013018000), Diabetes and Endocrinology (013241530), Pediatrics/Urology/Gynecology/Endocrinology (013240400)

Related research output

Ekelund, M., 2010, Department of Clinical Sciences, Lund University. 125 p.

Research output: ThesisDoctoral Thesis (compilation)

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