Segmental variation in microstructure, matrix synthesis and cell proliferation in rabbit flexor tendon

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Segmental variation in microstructure, matrix synthesis and cell proliferation in rabbit flexor tendon. / Abrahamsson, Sven Olof; Lundborg, Goran; Lohmander, Stefan.

In: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, Vol. 23, No. 3, 1989, p. 191-198.

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TY - JOUR

T1 - Segmental variation in microstructure, matrix synthesis and cell proliferation in rabbit flexor tendon

AU - Abrahamsson, Sven Olof

AU - Lundborg, Goran

AU - Lohmander, Stefan

PY - 1989

Y1 - 1989

N2 - An experimental culture system was designed with the purpose of studying matrix synthesis and cell proliferation in the deep flexor tendon of the rabbit fore-paw. Special attention was paid to differences between three consecutive defined segments of the tendon from the region of the tendon sheath. There were two fibrocartilaginous areas in the tendon, one in the dorsal part of the proximal segment and one in the volar part of the distal segment. The intermediate segment consisted of regular tendinous tissue. The dorsal aspect of the distal segment was further characterized by a cell rich area related to the entrance of the vinculum longum. Proteoglycan synthesis in vitro was higher in the proximal and distal segments than in the intermediate, while collagen synthesis was highest in the intermediate tendinous segment. Variations in collagen content were reflected in variations in collagen synthesis. The rate of cell proliferation was highest in the intermediate segment. Segmental biochemical characteristics correlated well with morphological variations of the deep flexor tendon. These variations may reflect an adaptation to different mechanical forces acting on the tendon. The segmental variations may also be relevant for the healing capacity of the flexor tendon.

AB - An experimental culture system was designed with the purpose of studying matrix synthesis and cell proliferation in the deep flexor tendon of the rabbit fore-paw. Special attention was paid to differences between three consecutive defined segments of the tendon from the region of the tendon sheath. There were two fibrocartilaginous areas in the tendon, one in the dorsal part of the proximal segment and one in the volar part of the distal segment. The intermediate segment consisted of regular tendinous tissue. The dorsal aspect of the distal segment was further characterized by a cell rich area related to the entrance of the vinculum longum. Proteoglycan synthesis in vitro was higher in the proximal and distal segments than in the intermediate, while collagen synthesis was highest in the intermediate tendinous segment. Variations in collagen content were reflected in variations in collagen synthesis. The rate of cell proliferation was highest in the intermediate segment. Segmental biochemical characteristics correlated well with morphological variations of the deep flexor tendon. These variations may reflect an adaptation to different mechanical forces acting on the tendon. The segmental variations may also be relevant for the healing capacity of the flexor tendon.

KW - Anatomy

KW - Cell proliferation

KW - Collagen

KW - Histology

KW - Protein

KW - Proteoglycan

KW - Tendon

UR - http://www.scopus.com/inward/record.url?scp=0024786229&partnerID=8YFLogxK

U2 - 10.3109/02844318909075117

DO - 10.3109/02844318909075117

M3 - Article

VL - 23

SP - 191

EP - 198

JO - Journal of Plastic Surgery and Hand Surgery

JF - Journal of Plastic Surgery and Hand Surgery

SN - 2000-656X

IS - 3

ER -