Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin

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Bibtex

@article{c351f9da66cf45f89da95c4c4e88c4e2,
title = "Selective enhancement of synthesis of interleukin-2 in lymphocytes in the presence of ciprofloxacin",
abstract = "A study was performed to verify the effect of ciprofloxacin on the production of interleukin-2 and other cytokines in cultures of human peripheral lymphocytes. In the presence of ciprofloxacin, lymphocytes demonstrated increased synthesis of interleukin-2 (100-fold, 7-fold and 1.5-fold increase at ciprofloxacin concentrations of 80, 20 and 5 μg/ml respectively), as measured by radioimmunoassay. Synthesis of other cytokines from T lymphocytes, gamma-interferon, lymphotoxin and granulocyte-macrophage colony stimulating factor as well as interleukin-1 and tumour necrosis factor from monocytes was not increased, but inhibited at a ciprofloxacin concentration of 80 μg/ml. Thus the effect of ciprofloxacin resulting in enhanced synthesis of interleukin-2 seems to be specific.",
author = "K. Riesbeck and A. Forsgren",
year = "1990",
month = "6",
day = "1",
doi = "10.1007/BF01979471",
language = "English",
volume = "9",
pages = "409--413",
journal = "European Journal of Clinical Microbiology and Infectious Diseases",
issn = "0934-9723",
publisher = "Springer",
number = "6",

}