Selective removal of 17 beta-estradiol at trace concentration using a molecularly imprinted polymer

TY - JOUR

T1 - Selective removal of 17 beta-estradiol at trace concentration using a molecularly imprinted polymer

AU - Le Noir, Mathieu

AU - Lepeuple, Anne-Sophie

AU - Guieysse, Benoit

AU - Mattiasson, Bo

PY - 2007

Y1 - 2007

N2 - A molecularly imprinted polymer (MIP) was synthesized with 17 beta-estradiol (E2) as template. It was then capable to recover this compound by 100 +/- 0.6% from a 2 mu g/L aqueous solution. By comparison, E2 recoveries of 77 +/- 5.2%, 87.1 +/- 2.3% and 19.1 +/- 7.8%, were achieved using a non-imprinted polymer (NIP) synthesized under the same conditions (but without template), a commercial C18 extraction phase and granular-activated carbon (GAC), respectively When fluoxetine hydrochloride and acenaphthene were added as interferences to the aqueous solution at 2 mu g/L each, E2 was recovered by 95.5 +/- 4.0% from the MIP, compared to 54.5 +/- 9.4%, 76.0 +/- 2% and 14.3 +/- 0.1% from the NIP, C18 and GAC phases, respectively Estrogenic activity equivalent to the effect caused by 22.4ng E2/L was recorded in the MIP extract from a wastewater sample whereas no activity was detected in the NIP extract. This suggested the imprinted polymers removed estrogenic compounds. This study therefore demonstrates the potential of MIPs for the selective removal of endocrine-disrupting compounds. By using a synthetic analogue to natural hormone receptors, adsorption is based on the same property that makes the contaminants harmful. Biological treatment of enriched E2 was also demonstrated. (c) 2007 Elsevier Ltd. All rights reserved.

AB - A molecularly imprinted polymer (MIP) was synthesized with 17 beta-estradiol (E2) as template. It was then capable to recover this compound by 100 +/- 0.6% from a 2 mu g/L aqueous solution. By comparison, E2 recoveries of 77 +/- 5.2%, 87.1 +/- 2.3% and 19.1 +/- 7.8%, were achieved using a non-imprinted polymer (NIP) synthesized under the same conditions (but without template), a commercial C18 extraction phase and granular-activated carbon (GAC), respectively When fluoxetine hydrochloride and acenaphthene were added as interferences to the aqueous solution at 2 mu g/L each, E2 was recovered by 95.5 +/- 4.0% from the MIP, compared to 54.5 +/- 9.4%, 76.0 +/- 2% and 14.3 +/- 0.1% from the NIP, C18 and GAC phases, respectively Estrogenic activity equivalent to the effect caused by 22.4ng E2/L was recorded in the MIP extract from a wastewater sample whereas no activity was detected in the NIP extract. This suggested the imprinted polymers removed estrogenic compounds. This study therefore demonstrates the potential of MIPs for the selective removal of endocrine-disrupting compounds. By using a synthetic analogue to natural hormone receptors, adsorption is based on the same property that makes the contaminants harmful. Biological treatment of enriched E2 was also demonstrated. (c) 2007 Elsevier Ltd. All rights reserved.

KW - molecular imprinting

KW - endocrine disrupter

KW - estrogen

KW - yeast estrogen screen

KW - trace contaminant

U2 - 10.1016/j.watres.2007.03.023

DO - 10.1016/j.watres.2007.03.023

M3 - Article

VL - 41

SP - 2825

EP - 2831

JO - Water Research

JF - Water Research

SN - 1879-2448

IS - 12

ER -