Sensing DNA–DNA as Nanosensor: A Perspective Towards Nanobiotechnology

Research output: Contribution to journalArticle

Abstract

Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employing single molecule fluorescence methods, we propose to make use of the physics of DNA denaturation nanoregions to find out about the solvent conditions such as ionic strength, presence of binding proteins, etc. Bymeasuring dynamical quantities in particular, rather sensitive nanoprobes may be constructed with contemporary instruments.

Details

Authors
External organisations
  • Nordic Institute for Theoretical Atomic Physics (NORDITA), Copenhagen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry
Original languageEnglish
Pages (from-to)389-395
JournalJournal of Computational and Theoretical Nanoscience
Volume2
Issue number3
Publication statusPublished - 2005 Sep 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes