Sensing DNA–DNA as Nanosensor: A Perspective Towards Nanobiotechnology

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Sensing DNA–DNA as Nanosensor: A Perspective Towards Nanobiotechnology. / Metzler, Ralf; Ambjörnsson, Tobias.

In: Journal of Computational and Theoretical Nanoscience, Vol. 2, No. 3, 01.09.2005, p. 389-395.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - Sensing DNA–DNA as Nanosensor: A Perspective Towards Nanobiotechnology

AU - Metzler, Ralf

AU - Ambjörnsson, Tobias

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employing single molecule fluorescence methods, we propose to make use of the physics of DNA denaturation nanoregions to find out about the solvent conditions such as ionic strength, presence of binding proteins, etc. Bymeasuring dynamical quantities in particular, rather sensitive nanoprobes may be constructed with contemporary instruments.

AB - Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employing single molecule fluorescence methods, we propose to make use of the physics of DNA denaturation nanoregions to find out about the solvent conditions such as ionic strength, presence of binding proteins, etc. Bymeasuring dynamical quantities in particular, rather sensitive nanoprobes may be constructed with contemporary instruments.

U2 - 10.1166/jctn.2005.209

DO - 10.1166/jctn.2005.209

M3 - Article

VL - 2

SP - 389

EP - 395

JO - Journal of Computational and Theoretical Nanoscience

JF - Journal of Computational and Theoretical Nanoscience

SN - 1546-1955

IS - 3

ER -