Sequence evolution in a chromosomal region of Arabidopsis thaliana

Research output: ThesisDoctoral Thesis (compilation)

Abstract

Recently there has been a lot of interest in the use of liknage disequilibrium (LD) in genome wide scans for new genes, so called association mapping. Of crucial importance to a genome wide scan for associations between genetic markers and the trait of interest is the extent of LD, as it determines both how closely a trait can be mapped and also how many markers is needed to map it. Most outbreeding organisms such as Drosophila melanogaster and maize have too little LD to be useful for association mapping. As LD breaks down much more slowly in predominantly self-fertilising organisms, they can, however, be expected to have much higher levels of LD.

It is shown here that the self-fertilising model plant Arabidopsis thaliana holds a lot of promise of being a suitable organism for LD-mapping. Around the flowering time locus FRI, the levels of LD were suitable for LD-mapping. Some of the problems with LD-mapping is also addressed as allelic heterogeneity had a major impact on LD in the region studied. Also some of the basic population genetic parameters for the region are discussed as is geographical subdivision among Arabidopsis thaliana and possible history of the different FRI alleles.

Details

Authors
  • Jenny Hagenblad
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Genetics

Keywords

  • Växtgenetik, Plant genetics, flowering time, mapping, polymorphism, Linkage disequilibrium, Arabidopsis thaliana
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
  • [unknown], [unknown], Supervisor, External person
Award date2002 Sep 21
Publisher
  • Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden,
Print ISBNs91-628-5356-2
Publication statusPublished - 2002
Publication categoryResearch

Bibliographic note

Defence details Date: 2002-09-21 Time: 10:00 Place: Genetics building, Sölveg. 29, Lund External reviewer(s) Name: Savolainen, Outi Title: Prof. Affiliation: [unknown] --- Article: Nordborg M, Borevitz JO, et al. The extent of Linkage Disequilibrium in Arabidopsis thaliana. Nature Genetics 30:190-193, 2002Hagenblad J, Nordborg M. Sequence variation and haplotype structure surrounding the flowering time locus FRI in Arabidopsis thaliana. Genetics 161:289-298, 2002Hagenblad J, Nordborg M. Molecular genetics of the allotetraploid Arabidopsis suecica and its parental species. Manuscript, 2002Hagenblad J, Nordborg M. Haplotype evolution around the locus FRI in Arabidopsis thaliana. Manuscript, 2002 The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Genetics (Closed 2011) (011005100)