SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Research output: Contribution to journalArticle


An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.


  • G Appendino
  • S Prosperini
  • Carola Valdivia
  • M Ballero
  • G Colombano
  • R A Billington
  • A A Genazzani
  • Olov Sterner
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)1213-1217
JournalJournal of Natural Products
Issue number8
Publication statusPublished - 2005
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)