SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis
Research output: Contribution to journal › Article
An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Journal of Natural Products|
|Publication status||Published - 2005|
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)