Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Research output: Contribution to journalArticle

Abstract

The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.

Details

Authors
Organisations
External organisations
  • University of Queensland
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)744-754
JournalDiabetologia
Volume59
Issue number4
Early online date2016 Jan 6
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes