Sertraline in symptomatic chronic breathlessness: a double blind, randomised trial

Research output: Contribution to journalArticle


Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25-100 mg (titrated upwards over 9 days) or placebo for 4 weeks. The primary outcome was the proportion who had an improvement in intensity of current breathlessness >15% from baseline on a 100-mm visual analogue scale.The proportion of people responding to sertraline was similar to placebo for current breathlessness on days 26-28 (OR 1.00, 95% CI 0.71-1.40) and for other measures of breathlessness. Quality of life in the sertraline arm had a higher likelihood of improving than in the placebo arm over the 4 weeks (OR 0.21, 95% CI 0.01-0.41; p=0.044). No differences in performance status, anxiety and depression, or survival were observed. Adverse event rates were similar between arms.Sertraline does not appear to provide any benefit over placebo in the symptomatic relief of chronic breathlessness in this patient population.


  • David C. Currow
  • Magnus Ekström
  • Sandra Louw
  • Julie Hill
  • Belinda Fazekas
  • Katherine Clark
  • Patricia M. Davidson
  • Christine McDonald
  • Dimitar Sajkov
  • Nikki McCaffrey
  • Matthew Doogue
  • Amy P. Abernethy
  • Meera Agar
External organisations
  • University of Technology Sydney
  • Flinders University
  • University of Sydney
  • Johns Hopkins University
  • Austin Health
  • Flinders Medical Centre
  • Deakin University
  • University of Otago
  • Duke University
  • McCloud Consulting Group
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Family Medicine
Original languageEnglish
Article number1801270
JournalThe European respiratory journal
Issue number1
Publication statusPublished - 2019
Publication categoryResearch