Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system

Research output: Contribution to journalArticle

Abstract

Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected rats. These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Infectious Medicine

Keywords

  • bradykinin, factor XII, high molecular weight kininogen, plasma kallikrein, protease inhibitor
Original languageEnglish
Pages (from-to)1415-1424
JournalJournal of Experimental Medicine
Volume192
Issue number10
Publication statusPublished - 2000
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (BMC) (013024020), Pathology, (Lund) (013030000), Department of Experimental Medical Science (013210000)