Side localization of parathyroid adenomas by simplified intraoperative venous sampling for parathyroid hormone

Research output: Contribution to journalArticle

Abstract

Side localization of parathyroid adenomas was performed by venous sampling for intact parathyroid hormone (PTH) in 20 consecutive patients with primary hyperparathyroidism (pHPT) after induction of anesthesia. The results were thus available during surgery. Nineteen of the patients had solitary parathyroid adenoma, and one had hyperplasia. There was no complication to the procedure. A lateralizing PTH gradient for a parathyroid adenoma was obtained in 13 patients. At surgery 12 of them (92%) were proved correct; that is, the adenoma was localized on the same side. Thus the technique correctly lateralized the adenoma in 12 of 19 patients (63%). We therefore conclude that the method of intraoperative venous sampling for intact PTH is safe, and the predictive value of a lateralizing gradient is high. It could therefore be used as an adjunct to surgical skill and noninvasive localization procedures in selected cases, for instance in patients with prior neck surgery and hypercalcemic crisis.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery
  • Anesthesiology and Intensive Care

Keywords

  • Adenoma, Adult, Aged, Female, Humans, Intraoperative Complications, Male, Middle Aged, Parathyroid Hormone, Parathyroid Neoplasms, Parathyroidectomy, Veins, Journal Article, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)358-60
Number of pages3
JournalWorld Journal of Surgery
Volume20
Issue number3
Publication statusPublished - 1996 Mar 1
Publication categoryResearch
Peer-reviewedYes