Simulation of stroke-related damage in cultured human nerve cells

Research output: Contribution to journalArticle

Abstract

We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human model neurons should eventually serve to reduce the number of experimental animals in cerebral stroke research.

Details

Authors
  • Gerd Bicker
  • Andrea Gierse
  • Saime Tan
  • Francois Paquet-Durand
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Ophthalmology

Keywords

  • reduction, organ-specific, brain-cell cultures, human, neuroprotection, neural differentiation, ischaemia, excitotoxicity, glutamate, replacement, pharmacological testing
Original languageEnglish
Pages (from-to)16-18
JournalALTEX Alternatives To Animal Experimentation
Volume24
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes