Six-week follow-up after HIV-1 exposure: a position statement from the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy.

Research output: Contribution to journalArticle

Abstract

In 2014 the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy (RAV) conducted a review and analysis of the state of knowledge on the duration of follow-up after exposure to human immunodeficiency virus (HIV). Up until then a follow-up of 12 weeks after exposure had been recommended, but improved tests and new information on early diagnosis motivated a re-evaluation of the national recommendations by experts representing infectious diseases and microbiology, county medical officers, the RAV, the Public Health Agency, and other national authorities. Based on the current state of knowledge the Public Health Agency of Sweden and the RAV recommend, starting in April 2015, a follow-up period of 6 weeks after possible HIV-1 exposure, if HIV testing is performed using laboratory-based combination tests detecting both HIV antibody and antigen. If point-of-care rapid HIV tests are used, a follow-up period of 8 weeks is recommended, because currently available rapid tests have insufficient sensitivity for detection of HIV-1 antigen. A follow-up period of 12 weeks is recommended after a possible exposure for HIV-2, since presently used assays do not include HIV-2 antigens and only limited information is available on the development of HIV antibodies during early HIV-2 infection. If pre- or post-exposure prophylaxis is administered, the follow-up period is recommended to begin after completion of prophylaxis. Even if infection cannot be reliably excluded before the end of the recommended follow-up period, HIV testing should be performed at first contact for persons who seek such testing.

Details

Authors
  • Hans Gaines
  • Jan Albert
  • Maria Axelsson
  • Torsten Berglund
  • Magnus Gisslén
  • Anders Sönnerborg
  • Anders Blaxhult
  • Gordana Bogdanovic
  • Maria Brytting
  • Christina Carlander
  • Leo Flamholc
  • Per Follin
  • Axana Haggar
  • Per Hagstam
  • Marcus Johansson
  • Lars Navér
  • Jenny Persson Blom
  • Agneta Samuelson
  • Helena Ström
  • Martin Sundqvist
  • And 4 others
  • Veronica Svedhem Johansson
  • Karin Tegmark Wisell
  • Anders Tegnell
  • Rigmor Thorstensson
Organisations
External organisations
  • Swedish Reference Group for Antiviral Therapy
  • Karolinska Institutet
  • Karolinska University Hospital
  • University of Gothenburg
  • Public Health Agency of Sweden
  • Södersjukhuset
  • Västmanland Hospital
  • Västra Götalandsregionen
  • Socialstyrelsen / Swedish National Board of Health and Welfare
  • Örebro University Hospital
  • Kalmar County Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
Original languageEnglish
Pages (from-to)1-6
JournalInfectious Diseases
Issue numbersep 28
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Faculty of Medicine (000022000), Division of Infection Medicine (SUS) (013008000), Infectious Diseases Research Unit (013242010)