Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis

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Bibtex

@article{c65a849ed251468fa146465602546368,
title = "Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis",
abstract = "MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. There are more than 500 miRNA genes reported in the human genome, constituting one of the largest classes of regulatory genes. Increasing experimental evidence supports the idea of aberrant miRNA expression in cancer pathogenesis. We analyzed the pattern of miRNA expression in chronic lymphocytic leukemia (CLL) cells and our results showed a global reduction in miRNA expression levels in CLL cells associated to a consistent underexpression of miR-181a, let-7a and miR-30d. We observed overexpression of miR-155 and a set of five miRNAs that are differentially expressed between patients with different clinical outcomes. Five novel miRNA candidates cloned from leukemic cells are reported. Surprisingly, predicted mRNA targets for these novel miRNA revealed a high proportion of targets located in a small region of chromosome",
author = "S Marton and MR Garcia and C Robello and Helena Persson and F Trajtenberg and O Pritsch and Carlos Rovira and H Naya and G Dighiero and A. Cayota",
year = "2008",
doi = "10.1038/sj.leu.2405022",
language = "English",
volume = "22",
pages = "330--338",
journal = "Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K",
issn = "1476-5551",
publisher = "Nature Publishing Group",
number = "2",

}