Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis

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Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. / Marton, S; Garcia, MR; Robello, C; Persson, Helena; Trajtenberg, F; Pritsch, O; Rovira, Carlos; Naya, H; Dighiero, G; Cayota, A.

In: Leukemia, Vol. 22, No. 2, 2008, p. 330-338.

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Marton, S ; Garcia, MR ; Robello, C ; Persson, Helena ; Trajtenberg, F ; Pritsch, O ; Rovira, Carlos ; Naya, H ; Dighiero, G ; Cayota, A. / Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. In: Leukemia. 2008 ; Vol. 22, No. 2. pp. 330-338.

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TY - JOUR

T1 - Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis

AU - Marton, S

AU - Garcia, MR

AU - Robello, C

AU - Persson, Helena

AU - Trajtenberg, F

AU - Pritsch, O

AU - Rovira, Carlos

AU - Naya, H

AU - Dighiero, G

AU - Cayota, A.

PY - 2008

Y1 - 2008

N2 - MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. There are more than 500 miRNA genes reported in the human genome, constituting one of the largest classes of regulatory genes. Increasing experimental evidence supports the idea of aberrant miRNA expression in cancer pathogenesis. We analyzed the pattern of miRNA expression in chronic lymphocytic leukemia (CLL) cells and our results showed a global reduction in miRNA expression levels in CLL cells associated to a consistent underexpression of miR-181a, let-7a and miR-30d. We observed overexpression of miR-155 and a set of five miRNAs that are differentially expressed between patients with different clinical outcomes. Five novel miRNA candidates cloned from leukemic cells are reported. Surprisingly, predicted mRNA targets for these novel miRNA revealed a high proportion of targets located in a small region of chromosome

AB - MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. There are more than 500 miRNA genes reported in the human genome, constituting one of the largest classes of regulatory genes. Increasing experimental evidence supports the idea of aberrant miRNA expression in cancer pathogenesis. We analyzed the pattern of miRNA expression in chronic lymphocytic leukemia (CLL) cells and our results showed a global reduction in miRNA expression levels in CLL cells associated to a consistent underexpression of miR-181a, let-7a and miR-30d. We observed overexpression of miR-155 and a set of five miRNAs that are differentially expressed between patients with different clinical outcomes. Five novel miRNA candidates cloned from leukemic cells are reported. Surprisingly, predicted mRNA targets for these novel miRNA revealed a high proportion of targets located in a small region of chromosome

U2 - 10.1038/sj.leu.2405022

DO - 10.1038/sj.leu.2405022

M3 - Article

VL - 22

SP - 330

EP - 338

JO - Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K

T2 - Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K

JF - Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K

SN - 1476-5551

IS - 2

ER -