Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study

Research output: Contribution to journalArticle

Standard

Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe : An Update on the EPIC Cohorts Study. / Cirera, Lluís; Huerta, José María; Chirlaque, María Dolores; Overvad, Kim; Lindström, Martin; Regnér, Sara; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Fagherazzi, Guy; Katzke, Verena A; Boeing, Heiner; Peppa, Eleni; Trichopoulou, Antonia; Valanou, Elissavet; Palli, Domenico; Grioni, Sara; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; van Gils, Carla; Vermeulen, Roel C H; Skeie, Guri; Braaten, Tonje; Weiderpass, Elisabete; Merino, Susana; Sánchez, María José; Larrañaga, Nerea; Ardanaz, Eva; Sund, Malin; Khaw, Kay-Tee; Key, Timothy J; Jenab, Mazda; Naudin, Sabine; Murphy, Neil; Aune, Dagfinn; Ward, Heather; Riboli, Elio; Bueno-de-Mesquita, Bas; Navarro, Carmen; Duell, Eric J.

In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 28, No. 6, 2019, p. 1089-1092.

Research output: Contribution to journalArticle

Harvard

Cirera, L, Huerta, JM, Chirlaque, MD, Overvad, K, Lindström, M, Regnér, S, Tjønneland, A, Boutron-Ruault, M-C, Rebours, V, Fagherazzi, G, Katzke, VA, Boeing, H, Peppa, E, Trichopoulou, A, Valanou, E, Palli, D, Grioni, S, Panico, S, Tumino, R, Ricceri, F, van Gils, C, Vermeulen, RCH, Skeie, G, Braaten, T, Weiderpass, E, Merino, S, Sánchez, MJ, Larrañaga, N, Ardanaz, E, Sund, M, Khaw, K-T, Key, TJ, Jenab, M, Naudin, S, Murphy, N, Aune, D, Ward, H, Riboli, E, Bueno-de-Mesquita, B, Navarro, C & Duell, EJ 2019, 'Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 28, no. 6, pp. 1089-1092. https://doi.org/10.1158/1055-9965.EPI-18-1153

APA

CBE

Cirera L, Huerta JM, Chirlaque MD, Overvad K, Lindström M, Regnér S, Tjønneland A, Boutron-Ruault M-C, Rebours V, Fagherazzi G, Katzke VA, Boeing H, Peppa E, Trichopoulou A, Valanou E, Palli D, Grioni S, Panico S, Tumino R, Ricceri F, van Gils C, Vermeulen RCH, Skeie G, Braaten T, Weiderpass E, Merino S, Sánchez MJ, Larrañaga N, Ardanaz E, Sund M, Khaw K-T, Key TJ, Jenab M, Naudin S, Murphy N, Aune D, Ward H, Riboli E, Bueno-de-Mesquita B, Navarro C, Duell EJ. 2019. Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 28(6):1089-1092. https://doi.org/10.1158/1055-9965.EPI-18-1153

MLA

Vancouver

Author

Cirera, Lluís ; Huerta, José María ; Chirlaque, María Dolores ; Overvad, Kim ; Lindström, Martin ; Regnér, Sara ; Tjønneland, Anne ; Boutron-Ruault, Marie-Christine ; Rebours, Vinciane ; Fagherazzi, Guy ; Katzke, Verena A ; Boeing, Heiner ; Peppa, Eleni ; Trichopoulou, Antonia ; Valanou, Elissavet ; Palli, Domenico ; Grioni, Sara ; Panico, Salvatore ; Tumino, Rosario ; Ricceri, Fulvio ; van Gils, Carla ; Vermeulen, Roel C H ; Skeie, Guri ; Braaten, Tonje ; Weiderpass, Elisabete ; Merino, Susana ; Sánchez, María José ; Larrañaga, Nerea ; Ardanaz, Eva ; Sund, Malin ; Khaw, Kay-Tee ; Key, Timothy J ; Jenab, Mazda ; Naudin, Sabine ; Murphy, Neil ; Aune, Dagfinn ; Ward, Heather ; Riboli, Elio ; Bueno-de-Mesquita, Bas ; Navarro, Carmen ; Duell, Eric J. / Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe : An Update on the EPIC Cohorts Study. In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2019 ; Vol. 28, No. 6. pp. 1089-1092.

RIS

TY - JOUR

T1 - Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe

T2 - An Update on the EPIC Cohorts Study

AU - Cirera, Lluís

AU - Huerta, José María

AU - Chirlaque, María Dolores

AU - Overvad, Kim

AU - Lindström, Martin

AU - Regnér, Sara

AU - Tjønneland, Anne

AU - Boutron-Ruault, Marie-Christine

AU - Rebours, Vinciane

AU - Fagherazzi, Guy

AU - Katzke, Verena A

AU - Boeing, Heiner

AU - Peppa, Eleni

AU - Trichopoulou, Antonia

AU - Valanou, Elissavet

AU - Palli, Domenico

AU - Grioni, Sara

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - van Gils, Carla

AU - Vermeulen, Roel C H

AU - Skeie, Guri

AU - Braaten, Tonje

AU - Weiderpass, Elisabete

AU - Merino, Susana

AU - Sánchez, María José

AU - Larrañaga, Nerea

AU - Ardanaz, Eva

AU - Sund, Malin

AU - Khaw, Kay-Tee

AU - Key, Timothy J

AU - Jenab, Mazda

AU - Naudin, Sabine

AU - Murphy, Neil

AU - Aune, Dagfinn

AU - Ward, Heather

AU - Riboli, Elio

AU - Bueno-de-Mesquita, Bas

AU - Navarro, Carmen

AU - Duell, Eric J

N1 - ©2019 American Association for Cancer Research.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: To analyze the potential effect of social inequality on pancreatic cancer risk in Western Europe, by reassessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, including a larger number of cases and an extended follow-up.METHODS: Data on highest education attained were gathered for 459,170 participants (70% women) from 10 European countries. A relative index of inequality (RII) based on adult education was calculated for comparability across countries and generations. Cox regression models were applied to estimate relative inequality in pancreatic cancer risk, stratifying by age, gender, and center, and adjusting for known pancreatic cancer risk factors.RESULTS: A total of 1,223 incident pancreatic cancer cases were included after a mean follow-up of 13.9 (±4.0) years. An inverse social trend was found in models adjusted for age, sex, and center for both sexes [HR of RII, 1.27; 95% confidence interval (CI), 1.02-1.59], which was also significant among women (HR, 1.42; 95% CI, 1.05-1.92). Further adjusting by smoking intensity, alcohol consumption, body mass index, prevalent diabetes, and physical activity led to an attenuation of the RII risk and loss of statistical significance.CONCLUSIONS: The present reanalysis does not sustain the existence of an independent social inequality influence on pancreatic cancer risk in Western European women and men, using an index based on adult education, the most relevant social indicator linked to individual lifestyles, in a context of very low pancreatic cancer survival from (quasi) universal public health systems.IMPACT: The results do not support an association between education and risk of pancreatic cancer.

AB - BACKGROUND: To analyze the potential effect of social inequality on pancreatic cancer risk in Western Europe, by reassessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, including a larger number of cases and an extended follow-up.METHODS: Data on highest education attained were gathered for 459,170 participants (70% women) from 10 European countries. A relative index of inequality (RII) based on adult education was calculated for comparability across countries and generations. Cox regression models were applied to estimate relative inequality in pancreatic cancer risk, stratifying by age, gender, and center, and adjusting for known pancreatic cancer risk factors.RESULTS: A total of 1,223 incident pancreatic cancer cases were included after a mean follow-up of 13.9 (±4.0) years. An inverse social trend was found in models adjusted for age, sex, and center for both sexes [HR of RII, 1.27; 95% confidence interval (CI), 1.02-1.59], which was also significant among women (HR, 1.42; 95% CI, 1.05-1.92). Further adjusting by smoking intensity, alcohol consumption, body mass index, prevalent diabetes, and physical activity led to an attenuation of the RII risk and loss of statistical significance.CONCLUSIONS: The present reanalysis does not sustain the existence of an independent social inequality influence on pancreatic cancer risk in Western European women and men, using an index based on adult education, the most relevant social indicator linked to individual lifestyles, in a context of very low pancreatic cancer survival from (quasi) universal public health systems.IMPACT: The results do not support an association between education and risk of pancreatic cancer.

U2 - 10.1158/1055-9965.EPI-18-1153

DO - 10.1158/1055-9965.EPI-18-1153

M3 - Article

VL - 28

SP - 1089

EP - 1092

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1538-7755

IS - 6

ER -