Solid-liquid interface method (SLIM): a new crystallization method for proteins

Research output: Contribution to journalArticle


Despite impressive advances in theories, methods and technologies, crystallization still remains a serious bottleneck in structural determination of macromolecules. Here we present a novel solid-liquid interface method (SLIM) for protein crystallization, based on the pre-adding and drying of a crystallization reagent, and thereafter the dispensing of a protein solution to the dried media to initiate crystallization from the solid-liquid interface. Not only quick and easy to perform, the method also allows for a less concentrated protein solution for setting up crystallization trials.


  • Erik Brostromer
  • Jie Nan
  • Lan-Fen Li
  • Xiao-Dong Su
External organisations
  • Peking University
Research areas and keywords


  • Crystallization, Proteins
Original languageEnglish
Pages (from-to)634-8
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number4
Publication statusPublished - 2009 Sep 4
Publication categoryResearch