Soluble adhesion molecules and angiotensin-converting enzyme in dementia.

Research output: Contribution to journalArticle

Abstract

We aimed to determine plasma and cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and platelet endothelial cell adhesion molecule-1 (sPECAM-1) as surrogate markers for endothelial cell activation in clinically diagnosed patients with Alzheimer's disease (AD, n=260), dementia with Lewy bodies (DLB, n=39) and non-demented controls (n=34). Plasma sICAM-1 and sPECAM-1 were higher and CSF sVCAM-1 were lower in AD and DLB patients than in controls (p < 0.001). DLB patients had higher CSF sICAM-1, but lower CSF sVCAM-1 (p < 0.001). No difference in ACE levels was found between the dementia groups and controls. In controls and AD patients CSF sICAM and sVCAM-1 strongly correlated with each other and with blood barrier permeability whereas in DLB group these correlations were weaker. The observed patterns in adhesion molecules may reflect distinctions in the pathophysiological basis of their generation in dementia patients.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)27-35
JournalNeurobiology of Disease
Volume26
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Chronic Inflammatory and Degenerative Diseases Research Unit (013242530), Psychiatry/Primary Care/Public Health (013240500)

Related research output

Nielsen, H., 2007, Chronic Inflammatory and Degenerative Diseases Research Unit.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)