Some substances with proposed digitalis-like effects evaluated on platelet functions sensitive for cardiac glycosides

Research output: Contribution to journalArticle

Abstract

1. 1. The effects of progresterone, corticosterone 21-acetate, chlormadinone acetate, dehydroepi-androsterone 3-sulfate and lysophosphatidylcholine were tested on 86Rb-uptake, 3H-5-HT-uptake, ADP-induced aggregation and 5-HT-induced shape change in human platelets. Ouabain and digoxin were used for reference. 2. 2. Ouabain and digoxin 10-5 M inhibited 86Rb-uptake by more than 85%, and chlormadinone acetate 10-5 M by 20%. The other substances had no effects. 3. 3. Ouabain and digoxin were potent inhibitors on 3H-5-HT-uptake, whereas chlormadinone acetate had no effect. 4. 4. Ouabain and digoxin increased ADP-induced aggregation but chlormadinone acetate decreased it. 5-HT-induced shape change was decreased by ouabain and digoxin, and to a lesser extent by chlormadinone acetate and its vehicle (ethanol 1.0%).

Details

Authors
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
Original languageEnglish
Pages (from-to)749-753
Number of pages5
JournalGeneral Pharmacology
Volume22
Issue number4
Publication statusPublished - 1991 Jan 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes