SOX11 and HIG-2 are cross-regulated and affect growth in mantle cell lymphoma.

Research output: Contribution to journalArticle

Abstract

The transcriptional factor SOX11 is a disease-defining antigen in mantle cell lymphoma (MCL) and absent in most non-malignant tissues. To explore the role of SOX11-related cell signaling, and potentially take benefit from these for targeted therapy, associated networks and proteins need to be defined. In this study, we used an inducible SOX11 knock-down system followed by gene expression analysis to identify co-regulated genes and associated signaling pathways. A limited number (n = 27) of significantly co-regulated genes were identified, including SETMAR, HIG-2, and CD24. Further analysis confirmed co-regulation of SOX11 with HIG-2 and CD24 at the protein level. Of major interest, knock-down of HIG-2 reduced SOX11 levels and increased proliferation, the proteins are thus cross-regulated. HIG-2 was localized at the plasma cell membrane in both cell lines and primary MCL cells, and could potentially be of interest for targeted therapy.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
JournalLeukemia & Lymphoma
Early online date2016 Jan 12
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes

Related research output

Venera Kuci, 2016, Department of Immunotechnology, Lund University.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)