Spare respiratory capacity, oxidative stress and excitotoxicity

Research output: Contribution to journalArticle

Abstract

Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. mitochondria play a central role in the survival or death of the exposed neuron. calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biochemistry and Molecular Biology

Keywords

  • oxidative, mitochondrion, ischaemia, glutamate, ATP, excitotoxicity, stress
Original languageEnglish
Pages (from-to)1385-1388
JournalBiochemical Society Transactions
Volume37
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)