Species-specific autoantibodies in type 1 diabetes

Research output: Contribution to journalArticle


title = "Species-specific autoantibodies in type 1 diabetes",
abstract = "GAD65 autoantibodies (GAD65Ab) are important markers for type 1 (insulin-dependent) diabetes mellitus. Although most patients have GAD65Ab at the time of clinical diagnosis, there are also GAD65Ab-positive individuals in the population at low risk of developing type 1 diabetes. The aim of this study was to test the hypothesis that the GAD65Ab reactivity to GAD65 cloned from human, mouse, and rat in newly diagnosed type 1 diabetic patients differ from antibody-positive healthy individuals. Sera from 254 new-onset 0- to 34- yr-old type 1 diabetic patients and 270 controls were assayed for their reactivity to human, mouse, and rat GAD65. Among the type 1 diabetic patients there was a significant better binding of human GAD65 compared to either mouse (P = 0.03) or rat GAD65 (P = 0.0005). The preference for human GAD65 increased with increasing age at onset (P = 0.0002). This differentiation was not observed in 88 GAD65Ab-positive control subjects. Our data indicate that recognition of epitopes by GAD65Ab in type 1 diabetes is different from that in nontype 1 diabetes, GAD65Ab-positive individuals.",
author = "Hampe, {C. S.} and E. {\"O}rtqvist and O. Rolandsson and M. Landin-Olsson and C. T{\"o}rn and {\AA} {\AA}gren and B. Persson and Schranz, {D. B.} and {\AA} Lernmark",
year = "1999",
month = feb,
day = "17",
doi = "10.1210/jcem.84.2.5503",
language = "English",
volume = "84",
pages = "643--648",
journal = "The Journal of clinical endocrinology and metabolism",
issn = "1945-7197",
publisher = "Oxford University Press",
number = "2",