Species-specific autoantibodies in type 1 diabetes

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Species-specific autoantibodies in type 1 diabetes. / Hampe, C. S.; Örtqvist, E.; Rolandsson, O.; Landin-Olsson, M.; Törn, C.; Ågren, Å; Persson, B.; Schranz, D. B.; Lernmark, Å.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 84, No. 2, 17.02.1999, p. 643-648.

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Harvard

Hampe, CS, Örtqvist, E, Rolandsson, O, Landin-Olsson, M, Törn, C, Ågren, Å, Persson, B, Schranz, DB & Lernmark, Å 1999, 'Species-specific autoantibodies in type 1 diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 2, pp. 643-648. https://doi.org/10.1210/jcem.84.2.5503

APA

Hampe, C. S., Örtqvist, E., Rolandsson, O., Landin-Olsson, M., Törn, C., Ågren, Å., Persson, B., Schranz, D. B., & Lernmark, Å. (1999). Species-specific autoantibodies in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 84(2), 643-648. https://doi.org/10.1210/jcem.84.2.5503

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Author

Hampe, C. S. ; Örtqvist, E. ; Rolandsson, O. ; Landin-Olsson, M. ; Törn, C. ; Ågren, Å ; Persson, B. ; Schranz, D. B. ; Lernmark, Å. / Species-specific autoantibodies in type 1 diabetes. In: Journal of Clinical Endocrinology and Metabolism. 1999 ; Vol. 84, No. 2. pp. 643-648.

RIS

TY - JOUR

T1 - Species-specific autoantibodies in type 1 diabetes

AU - Hampe, C. S.

AU - Örtqvist, E.

AU - Rolandsson, O.

AU - Landin-Olsson, M.

AU - Törn, C.

AU - Ågren, Å

AU - Persson, B.

AU - Schranz, D. B.

AU - Lernmark, Å

PY - 1999/2/17

Y1 - 1999/2/17

N2 - GAD65 autoantibodies (GAD65Ab) are important markers for type 1 (insulin-dependent) diabetes mellitus. Although most patients have GAD65Ab at the time of clinical diagnosis, there are also GAD65Ab-positive individuals in the population at low risk of developing type 1 diabetes. The aim of this study was to test the hypothesis that the GAD65Ab reactivity to GAD65 cloned from human, mouse, and rat in newly diagnosed type 1 diabetic patients differ from antibody-positive healthy individuals. Sera from 254 new-onset 0- to 34- yr-old type 1 diabetic patients and 270 controls were assayed for their reactivity to human, mouse, and rat GAD65. Among the type 1 diabetic patients there was a significant better binding of human GAD65 compared to either mouse (P = 0.03) or rat GAD65 (P = 0.0005). The preference for human GAD65 increased with increasing age at onset (P = 0.0002). This differentiation was not observed in 88 GAD65Ab-positive control subjects. Our data indicate that recognition of epitopes by GAD65Ab in type 1 diabetes is different from that in nontype 1 diabetes, GAD65Ab-positive individuals.

AB - GAD65 autoantibodies (GAD65Ab) are important markers for type 1 (insulin-dependent) diabetes mellitus. Although most patients have GAD65Ab at the time of clinical diagnosis, there are also GAD65Ab-positive individuals in the population at low risk of developing type 1 diabetes. The aim of this study was to test the hypothesis that the GAD65Ab reactivity to GAD65 cloned from human, mouse, and rat in newly diagnosed type 1 diabetic patients differ from antibody-positive healthy individuals. Sera from 254 new-onset 0- to 34- yr-old type 1 diabetic patients and 270 controls were assayed for their reactivity to human, mouse, and rat GAD65. Among the type 1 diabetic patients there was a significant better binding of human GAD65 compared to either mouse (P = 0.03) or rat GAD65 (P = 0.0005). The preference for human GAD65 increased with increasing age at onset (P = 0.0002). This differentiation was not observed in 88 GAD65Ab-positive control subjects. Our data indicate that recognition of epitopes by GAD65Ab in type 1 diabetes is different from that in nontype 1 diabetes, GAD65Ab-positive individuals.

U2 - 10.1210/jcem.84.2.5503

DO - 10.1210/jcem.84.2.5503

M3 - Article

C2 - 10022431

AN - SCOPUS:0033018809

VL - 84

SP - 643

EP - 648

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

SN - 1945-7197

IS - 2

ER -