Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.

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Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice. / Bhattachariya, Anirban; Dahan, Diana; Ekman, Mari; Boettger, T; Braun, T; Swärd, Karl; Hellstrand, Per; Albinsson, Sebastian.

In: Acta Physiologica, Vol. 215, No. 3, 2015, p. 133-143.

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T1 - Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.

AU - Bhattachariya, Anirban

AU - Dahan, Diana

AU - Ekman, Mari

AU - Boettger, T

AU - Braun, T

AU - Swärd, Karl

AU - Hellstrand, Per

AU - Albinsson, Sebastian

PY - 2015

Y1 - 2015

N2 - Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.

AB - Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.

U2 - 10.1111/apha.12536

DO - 10.1111/apha.12536

M3 - Article

VL - 215

SP - 133

EP - 143

JO - Acta Physiologica

T2 - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 3

ER -