Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

Research output: Contribution to journalArticle


title = "Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease",
abstract = "Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these simulations to observed patterns measured using tau-PET in 312 individuals along Alzheimer's disease continuum. Up to 70% of the variance in the overall spatial pattern of tau can be explained by our model. Surprisingly, the ESM predicts the spatial patterns of tau irrespective of whether brain Aβ is present, but regions with greater Aβ burden show greater tau than predicted by connectivity patterns, suggesting a role of Aβ in accelerating tau spread. Altogether, our results provide evidence in humans that tau spreads through neuronal communication pathways even in normal aging, and that this process is accelerated by the presence of brain Aβ.",
author = "Vogel, {Jacob W.} and Yasser Iturria-Medina and Strandberg, {Olof T.} and Ruben Smith and Elizabeth Levitis and Evans, {Alan C.} and Oskar Hansson and {Alzheimer's Disease Neuroimaging Initiative} and {Swedish BioFinder Study} and Jimmy L{\"a}tt and Markus Nilsson and Freddy St{\aa}hlberg and {Maly Sundgren}, Pia and {van Westen}, Danielle and Jonas J{\"o}gi and Douglas H{\"a}gerstr{\"o}m and Olsson, {Tomas G} and Per Wollmer",
year = "2020",
month = may,
day = "26",
doi = "10.1038/s41467-020-15701-2",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",