Stability of peptide-HLA-I complexes and tapasin folding facilitation - tools to define immunogenic peptides

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Bibtex

@article{b5209b6f19094cd6b5f5023b7758cc23,
title = "Stability of peptide-HLA-I complexes and tapasin folding facilitation - tools to define immunogenic peptides",
abstract = "Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes showed small differences in tapasin-facilitation and larger differences in stability. This suggests that the stability of immunogenic peptide-HLA-I complexes vary above an HLA-I allomorph dependent lower limit (e. g. > 2 h for HLA-A*02:01), immunogenicity predicted by tapasin-facilitation may be defined by an equally allomorph unique upper value (e. g. tapasin-facilitation <1.5 for HLA-A*02:01), and variation above the stability-threshold does not directly reflect a variation in tapasin-facilitation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.",
keywords = "Tapasin, MHC-I, Peptide, Stability, Vaccine",
author = "{Geironson Ulfsson}, Linda and Gustav Roder and Paulsson, {Kajsa M}",
year = "2012",
doi = "10.1016/j.febslet.2012.03.045",
language = "English",
volume = "586",
pages = "1336--1343",
journal = "FEBS Letters",
issn = "1873-3468",
publisher = "Wiley-Blackwell",
number = "9",

}