Standard Guidelines for the Chromosome-Centric Human Proteome Project

Research output: Contribution to journalArticle


The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-FIPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives ( The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.


  • Young-Ki Paik
  • Gilbert S. Omenn
  • Mathias Uhlen
  • Samir Hanash
  • Ruedi Aebersold
  • Amos Bairoch
  • Tadashi Yamamoto
  • Pierre Legrain
  • Hyoung-Joo Lee
  • Keun Na
  • Seul-Ki Jeong
  • Fuchu He
  • Pierre-Alain Binz
  • Toshihide Nishimura
  • Paul Keown
  • Mark S. Baker
  • Jong Shin Yoo
  • Jerome Garin
  • Alexander Archakov
  • John Bergeron
  • Ghasem Hosseini Salekdeh
  • William S. Hancock
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Engineering


  • antibody, Biology/Disease-Driven Human Proteome Project, Chromosome-Centric Human Proteome Project, Human Genome Project, Human, Proteome Project, Human Proteome Organization, knowledge-base, mass, spectrometry
Original languageEnglish
Pages (from-to)2005-2013
JournalJournal of Proteome Research
Issue number4
Publication statusPublished - 2012
Publication categoryResearch