Stardardization Developments for Large Scale Biobanks in Smoking Related Diseases - A Model System for Blood Sample Processing and Storage

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Bibtex

@article{6e78347a1f1f450ab2824cebff2413cd,
title = "Stardardization Developments for Large Scale Biobanks in Smoking Related Diseases - A Model System for Blood Sample Processing and Storage",
abstract = "Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples in clinical decision-making is highly dependent on their quality and integrity. New procedures that better preserve sample integrity and reduce degradation are being developed to meet the needs of both present and future biobanking. Hereby we present an automatic sample workflow scheme that is designed to handle high numbers of blood samples. Blood fractions are aliquoted, heat sealed using novel technology, and stored in 384 tube high-density sample arrays. The newly developed 384 biobank rack system is especially suited for preserving identical small aliquots. This technology development allows rapid access to a given sample in the frozen archive while maintaining individual sample integrity with sample tube confinement and quality management. We provide data on robotic processing of clinical samples at -80°C, following initial processing, analysis and shipping between laboratories throughout Europe. Subsequent to unpacking, re-sorting, and storage at these sites, the samples have been returned for analysis. Biomarker analysis of 13 common tests in the clinical chemistry unit of the hospital provides evidence of qualitative and stable logistics using the 384-sample tube system.",
keywords = "Biobank, Biomarkers, Standardization, Robotics, Respiratory diseases",
author = "Johan Malm and Thomas Fehniger and Pia Danmyr and {\'A}kos V{\'e}gv{\'a}ri and Charlotte Welinder and Henrik Lindberg and Paul Upton and Stephanie Carter and Roger Appelqvist and Karin Sj{\"o}din and Elisabet Wieslander and Magnus Dahlb{\"a}ck and Melinda Rezeli and David Erlinge and Gy{\"o}rgy Marko-Varga",
year = "2013",
doi = "10.1186/2213-0802-1-14",
language = "English",
volume = "1",
journal = "Translational Respiratory Medicine",
issn = "2213-0802",
publisher = "Springer Open",

}