Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.

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Abstract

Aldehyde dehydrogenase family 1 member A1 (ALDH1A1) is a putative marker of breast cancer stem cells (CSCs) with prognostic implications when expressed in cancer or stroma. However, previous results are contradictory and we therefore aimed to further evaluate the impact of ALDH1A1 on distant disease-free survival (DDFS) and correlation with clinicopathological variables in breast cancer, specifically by evaluating different cut-offs.

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  • Cancer and Oncology
Original languageEnglish
Pages (from-to)1012-1019
JournalJournal of Clinical Pathology
Volume68
Issue number12
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes