Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.

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T1 - Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.

AU - Sjöström, Martin

AU - Werner Hartman, Linda

AU - Honeth, Gabriella

AU - Grabau, Dorthe

AU - Malmström, Per

AU - Hegardt, Cecilia

AU - Fernö, Mårten

AU - Niméus, Emma

PY - 2015

Y1 - 2015

N2 - Aldehyde dehydrogenase family 1 member A1 (ALDH1A1) is a putative marker of breast cancer stem cells (CSCs) with prognostic implications when expressed in cancer or stroma. However, previous results are contradictory and we therefore aimed to further evaluate the impact of ALDH1A1 on distant disease-free survival (DDFS) and correlation with clinicopathological variables in breast cancer, specifically by evaluating different cut-offs.

AB - Aldehyde dehydrogenase family 1 member A1 (ALDH1A1) is a putative marker of breast cancer stem cells (CSCs) with prognostic implications when expressed in cancer or stroma. However, previous results are contradictory and we therefore aimed to further evaluate the impact of ALDH1A1 on distant disease-free survival (DDFS) and correlation with clinicopathological variables in breast cancer, specifically by evaluating different cut-offs.

U2 - 10.1136/jclinpath-2015-203092

DO - 10.1136/jclinpath-2015-203092

M3 - Article

VL - 68

SP - 1012

EP - 1019

JO - Journal of Clinical Pathology

T2 - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

SN - 1472-4146

IS - 12

ER -