Stem cell therapy for human neurodegenerative disorders-how to make it work

Research output: Contribution to journalReview article

Abstract

Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.

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  • Neurology
Original languageEnglish
Pages (from-to)S42-S50
JournalNature Reviews Neuroscience
Volume10
Issue numberSuppl.
Publication statusPublished - 2004
Publication categoryResearch
Peer-reviewedYes