Stimulation and inhibition of insulin release by an amino-reactive probe of plasma membrane

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Bibtex

@article{6950c68a47024aef92a25ee5cc917570,
title = "Stimulation and inhibition of insulin release by an amino-reactive probe of plasma membrane",
abstract = "4-Acetamido-4′-isothiocyanostilbene-2,2′-disulphonic acid (SITS), an amino-reacting probe of plasma membranes, stimulated the release of insulin from micro-dissected pancreatic islets of ob/ob-mice. This effect of SITS was inhibited by adrenaline or by calcium deficiency. SITS did not inhibit the insulin-releasing action of glucose or leucine but rather potentiated the effect of glucose. In contrast, SITS markedly depressed the insulin secretory response to chloromercuribenzene-p-sulphonic acid. It is suggested that by reacting with the plasma membranes SITS may induce secretagogic ionic fluxes in the β-cells. In addition, SITS apparently inhibits the secretagogic recognition of chloromercuribenzene-p-sulphonic acid, presumably by preventing the organic mercurial from reacting with certain membrane thiol groups.",
author = "Bo Hellman and Idahl, {Lars {\AA}ke} and {\AA}ke Lernmark and Janove Sehlin and T{\"a}ljedal, {Inge Bert}",
year = "1973",
month = dec,
day = "1",
doi = "10.1007/BF01868074",
language = "English",
volume = "14",
pages = "135--142",
journal = "Journal of Membrane Biology",
issn = "0022-2631",
publisher = "Springer",
number = "1",

}