Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma

Research output: Contribution to journalArticle

Abstract

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense stroma, which has a fundamental role in tumor progression. Fibronectin (FN1) is the main constituent of the tumor stroma in pancreatic cancer. This study aimed to explore the association between FN1 and clinicopathological characteristics and disease survival. Methods: Formalin-fixed paraffin-embedded tissue samples from 138 patients with PDAC were constructed into a tissue microarray, followed by immunohistochemical analysis with a recombinant monoclonal FN1 antibody. Chi-square test or Fisher's exact test were used for comparison of FN1 expression and relevant clinicopathological parameters. Kaplan-Meier survival curves and Cox regression analyses were used to assess the association between FN1 and survival. Results: FN1 was detected in the stromal compartment in most cases (117/138, 84.8%). Compared to the low FN1 expression group, the high FN1 expression group had significantly larger tumor size (P = 0.002), more advanced T stage (P = 0.039) and N stage (P = 0.009), and also worse AJCC stage (P = 0.003). However, stromal FN1 expression was not associated with disease-free survival or overall survival. Conclusions: This study suggests that high stromal FN1 expression is associated with aggressive tumor characteristics in patients with resected PDAC. However, no association between FN1 expression and survival was found.

Details

Authors
Organisations
External organisations
  • Wenzhou Medical University
  • Skåne University Hospital
  • The 2nd Affiliated Hospital & Yuying Children's Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Surgery

Keywords

  • Fibronectin, Immunohistochemistry, Pancreatic ductal adenocarcinoma, Survival
Original languageEnglish
Article number29
JournalWorld Journal of Surgical Oncology
Volume17
Issue number1
Publication statusPublished - 2019 Feb 8
Publication categoryResearch
Peer-reviewedYes

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