Structure and Function of Cu(I)- and Zn(II)-ATPases

Research output: Contribution to journalArticle

Abstract

Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.

Details

Authors
  • Oleg Sitsel
  • Christina Gronberg
  • Henriette Elisabeth Autzen
  • Kaituo Wang
  • Gabriele Meloni
  • Poul Nissen
  • Pontus Gourdon
Organisations
External organisations
  • University of Copenhagen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Structural Biology
  • Biochemistry and Molecular Biology
Original languageEnglish
Pages (from-to)5673-5683
JournalBiochemistry
Volume54
Issue number37
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes