Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate

Research output: Contribution to journalArticle

Abstract

The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.

Details

Authors
  • Dan Lundberg
  • Géraldine Lafitte
  • Helena Ljusberg
  • Pernilla Lennernaes
  • Krister Thuresson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry

Keywords

  • self-emulsifying drug-delivery system, mucin, microemulsion, Bioavailability, cationic amphiphile
Original languageEnglish
Pages (from-to)920-928
JournalJournal of Dispersion Science and Technology
Volume30
Issue number6
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes