Study of ATP-release from acoustically levitated eryhrocytes

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

Erythrocytes (red blood cells) are known to produce large amounts of Adenosine Triphosphate (ATP). It has recently become clear that the ATP-release is part of a mechanism controlling the dilation of the body’s blood vessels. The study of the erythrocyte’s behaviour is complicated by the fact that they respond easily to any physical contact. In this paper we propose a new method for studying the dynamics of the ATP-release by combining non-contact acoustic trapping in a microfluidic chip with a chemiluminiscent assay. Sensitivity levels down to 10 pM were achievable and the ATP-release from a cluster of levitated live erythrocytes was recorded.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Engineering

Keywords

  • Chemiluminiscence, Erythrocytes, ATP, Acoustic trapping
Original languageEnglish
Title of host publicationThe proceedings of micro total analysis systems 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1372-1374
Number of pages3
Volume2
ISBN (Print)978-0-9798064-0-7
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes
EventMicro Total Analysis Systems 2007 - Paris
Duration: 2007 Oct 72007 Oct 11

Publication series

Name
Volume2

Conference

ConferenceMicro Total Analysis Systems 2007
Period2007/10/072007/10/11

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Research output: Contribution to journalPublished meeting abstract

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