Subclinical atherosclerosis in patients with cyanotic congenital heart disease

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Subclinical atherosclerosis in patients with cyanotic congenital heart disease. / Tarp, Julie Bjerre; Sørgaard, Mathias Holm; Christoffersen, Christina; Jensen, Annette Schophuus; Sillesen, Henrik; Celermajer, David; Eriksson, Peter; Estensen, Mette Elise; Nagy, Edit; Holstein-Rathlou, Niels Henrik; Engstrøm, Thomas; Søndergaard, Lars.

In: International Journal of Cardiology, Vol. 277, 2019, p. 97-103.

Research output: Contribution to journalArticle

Harvard

Tarp, JB, Sørgaard, MH, Christoffersen, C, Jensen, AS, Sillesen, H, Celermajer, D, Eriksson, P, Estensen, ME, Nagy, E, Holstein-Rathlou, NH, Engstrøm, T & Søndergaard, L 2019, 'Subclinical atherosclerosis in patients with cyanotic congenital heart disease', International Journal of Cardiology, vol. 277, pp. 97-103. https://doi.org/10.1016/j.ijcard.2018.08.104

APA

Tarp, J. B., Sørgaard, M. H., Christoffersen, C., Jensen, A. S., Sillesen, H., Celermajer, D., Eriksson, P., Estensen, M. E., Nagy, E., Holstein-Rathlou, N. H., Engstrøm, T., & Søndergaard, L. (2019). Subclinical atherosclerosis in patients with cyanotic congenital heart disease. International Journal of Cardiology, 277, 97-103. https://doi.org/10.1016/j.ijcard.2018.08.104

CBE

Tarp JB, Sørgaard MH, Christoffersen C, Jensen AS, Sillesen H, Celermajer D, Eriksson P, Estensen ME, Nagy E, Holstein-Rathlou NH, Engstrøm T, Søndergaard L. 2019. Subclinical atherosclerosis in patients with cyanotic congenital heart disease. International Journal of Cardiology. 277:97-103. https://doi.org/10.1016/j.ijcard.2018.08.104

MLA

Vancouver

Tarp JB, Sørgaard MH, Christoffersen C, Jensen AS, Sillesen H, Celermajer D et al. Subclinical atherosclerosis in patients with cyanotic congenital heart disease. International Journal of Cardiology. 2019;277:97-103. https://doi.org/10.1016/j.ijcard.2018.08.104

Author

Tarp, Julie Bjerre ; Sørgaard, Mathias Holm ; Christoffersen, Christina ; Jensen, Annette Schophuus ; Sillesen, Henrik ; Celermajer, David ; Eriksson, Peter ; Estensen, Mette Elise ; Nagy, Edit ; Holstein-Rathlou, Niels Henrik ; Engstrøm, Thomas ; Søndergaard, Lars. / Subclinical atherosclerosis in patients with cyanotic congenital heart disease. In: International Journal of Cardiology. 2019 ; Vol. 277. pp. 97-103.

RIS

TY - JOUR

T1 - Subclinical atherosclerosis in patients with cyanotic congenital heart disease

AU - Tarp, Julie Bjerre

AU - Sørgaard, Mathias Holm

AU - Christoffersen, Christina

AU - Jensen, Annette Schophuus

AU - Sillesen, Henrik

AU - Celermajer, David

AU - Eriksson, Peter

AU - Estensen, Mette Elise

AU - Nagy, Edit

AU - Holstein-Rathlou, Niels Henrik

AU - Engstrøm, Thomas

AU - Søndergaard, Lars

PY - 2019

Y1 - 2019

N2 - Introduction: Survival in patients with cyanotic congenital heart disease (CCHD) has improved dramatically. The result is an ageing population with risk of acquired heart disease. Previous small uncontrolled studies suggested that these patients are protected against the development of atherosclerosis. To test this hypothesis, we sought to determine the prevalence of subclinical atherosclerosis in a larger population of patients with CCHD. Method: We compared the prevalence of subclinical atherosclerosis in adult CCHD patients from Denmark, Sweden, Norway and Australia, with that in age-, sex-, smoking status-, and body mass index matched controls. Coronary artery atherosclerosis was assessed on computed tomography with coronary artery calcification (CAC) score. Subclinical atherosclerosis was defined by CAC-score > 0. Carotid artery atherosclerosis was evaluated using ultrasound by measuring carotid plaque thickness (cPT-max) and carotid intima media thickness (CIMT). Lipid status was evaluated as an important atherosclerotic risk factor. Results: Seventy-four patients with CCHD (57% women, median age 49.5 years) and 74 matched controls (57% women, median age 50.0 years) were included. There were no differences between the groups in: CAC-score > 0 (21% vs. 19%, respectively; p = 0.8), carotid plaques (19% vs. 9%, respectively; p = 0.1), cPT-max (2.3 mm vs. 2.8 mm, respectively; p = 0.1) or CIMT (0.61 mm vs. 0.61 mm, respectively; p = 0.98). And further no significant differences in lipoprotein concentrations measured by ultracentrifugation. Conclusion: Young adults with CCHD have similar cardiovascular risk factor profiles and measures of subclinical atherosclerosis, compared with controls. Given their increasing life expectancies, athero-preventive strategies should be an important part of their clinical management.

AB - Introduction: Survival in patients with cyanotic congenital heart disease (CCHD) has improved dramatically. The result is an ageing population with risk of acquired heart disease. Previous small uncontrolled studies suggested that these patients are protected against the development of atherosclerosis. To test this hypothesis, we sought to determine the prevalence of subclinical atherosclerosis in a larger population of patients with CCHD. Method: We compared the prevalence of subclinical atherosclerosis in adult CCHD patients from Denmark, Sweden, Norway and Australia, with that in age-, sex-, smoking status-, and body mass index matched controls. Coronary artery atherosclerosis was assessed on computed tomography with coronary artery calcification (CAC) score. Subclinical atherosclerosis was defined by CAC-score > 0. Carotid artery atherosclerosis was evaluated using ultrasound by measuring carotid plaque thickness (cPT-max) and carotid intima media thickness (CIMT). Lipid status was evaluated as an important atherosclerotic risk factor. Results: Seventy-four patients with CCHD (57% women, median age 49.5 years) and 74 matched controls (57% women, median age 50.0 years) were included. There were no differences between the groups in: CAC-score > 0 (21% vs. 19%, respectively; p = 0.8), carotid plaques (19% vs. 9%, respectively; p = 0.1), cPT-max (2.3 mm vs. 2.8 mm, respectively; p = 0.1) or CIMT (0.61 mm vs. 0.61 mm, respectively; p = 0.98). And further no significant differences in lipoprotein concentrations measured by ultracentrifugation. Conclusion: Young adults with CCHD have similar cardiovascular risk factor profiles and measures of subclinical atherosclerosis, compared with controls. Given their increasing life expectancies, athero-preventive strategies should be an important part of their clinical management.

KW - Cardiovascular disease

KW - Carotid artery atherosclerosis

KW - Coronary artery atherosclerosis

KW - Coronary artery calcification

KW - Cyanotic congenital heart disease

KW - Hyperlipidemia

U2 - 10.1016/j.ijcard.2018.08.104

DO - 10.1016/j.ijcard.2018.08.104

M3 - Article

C2 - 30228018

AN - SCOPUS:85053317547

VL - 277

SP - 97

EP - 103

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -