Suicidal Intent and the HPA-Axis Characteristics of Suicide Attempters with Major Depressive Disorder and Adjustment Disorders.

Research output: Contribution to journalArticle


The main purpose of the study was to investigate Hypothalamic-Pituitary-Adrenal (HPA) axis characteristics in relation to suicidal intent among suicide attempters with Major Depressive Disorder (MDD) and Adjustment Disorders (AD). The relationship between suicidal intent, assessed by means of the Suicidal Intent Scale (SIS), and serum cortisol after a Dexamethasone Suppression Test (DST) was investigated in 78 suicide attempters, divided into diagnostic subgroups. There was a significant negative correlation between suicidal intent and post DST cortisol in patients with MDD. Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turnresults in a seemingly normal stress system.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Psychiatry


  • dexamethasone suppression test, adjustment disorders, HPA-axis, major depressive disorder, suicidal intent, suicide
Original languageEnglish
Pages (from-to)197-207
JournalArchives of Suicide Research
Issue number3
Publication statusPublished - 2008
Publication categoryResearch

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