Surgical Morbidity and Mortality From the Multicenter Randomized Controlled NeoRes II Trial: Standard Versus Prolonged Time to Surgery After Neoadjuvant Chemoradiotherapy for Esophageal Cancer

Research output: Contribution to journalArticle


OBJECTIVE: To investigate if prolonged TTS after completed nCRT improves postoperative outcomes for esophageal and esophagogastric junction cancer. SUMMARY OF BACKGROUND DATA: TTS has traditionally been 4-6 weeks after completed nCRT. However, the optimal timing is not known. METHODS: A multicenter clinical trial was performed with randomized allocation of TTS of 4-6 or 10-12 weeks. The primary endpoint of this sub-study was overall postoperative complications defined as Clavien-Dindo grade II-V. Secondary endpoints included complication severity according to Clavien-Dindo grade IIIb-V, postoperative 90-day mortality, and length of hospital stay. The study was registered in (NCT02415101). RESULTS: In total 249 patients were randomized. There were no significant differences between standard TTS and prolonged TTS with regard to overall incidence of complications Clavien-Dindo grade II-V (63.2% vs 72.6%, P = 0.134) or regarding Clavien-Dindo grade IIIb-V complications (31.6% vs 34.9%, P = 0.603). There were no statistically significant differences between standard and prolonged TTS regarding anastomotic leak (P = 0.596), conduit necrosis (P = 0.524), chyle leak (P = 0.427), pneumonia (P = 0.548), and respiratory failure (P = 0.723). In the standard TTS arm 5 patients (4.3%) died within 90 days of surgery, compared to 4 patients (3.8%) in the prolonged TTS arm (P = 1.0). Median length of hospital stay was 15 days in the standard TTS arm and 17 days in the prolonged TTS arm (P = 0.234). CONCLUSION: The timing of surgery after completed nCRT for carcinoma of the esophagus or esophagogastric junction, is not of major importance with regard to short-term postoperative outcomes.


  • Klara Nilsson
  • Fredrik Klevebro
  • Ioannis Rouvelas
  • Mats Lindblad
  • Eva Szabo
  • Ingvar Halldestam
  • Ulrika Smedh
  • Bengt Wallner
  • Jan Johansson
  • Gjermund Johnsen
  • Eirik Kjus Aahlin
  • Hans Olaf Johannessen
  • Geir Olav Hjortland
  • Isabel Bartella
  • Wolfgang Schröder
  • Christiane Bruns
  • Magnus Nilsson
External organisations
  • Karolinska University Hospital
  • Karolinska Institutet
  • Örebro University
  • Linköping University Hospital
  • Sahlgrenska University Hospital
  • Norrland University Hospital
  • Skåne University Hospital
  • St. Olav’s University Hospital
  • University Hospital of North Norway
  • Oslo university hospital
  • University of Cologne
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Surgery
Original languageEnglish
Pages (from-to)684-689
Number of pages6
JournalAnnals of Surgery
Issue number5
Publication statusPublished - 2020
Publication categoryResearch
Externally publishedYes