Surgical Site Infections in Dermatologic Surgery- Clinical, diagnostic, and pathogenic aspects
Research output: Thesis › Doctoral Thesis (compilation)
In study I, we examined bacterial dynamics during normal wound healing and SSIs. We found that quantifying bacteria from wounds was a relevant factor for assessing healing outcomes. Higher bac- terial loads in wounds resulted in complicated post- operative healing outcomes.
In study II, we designed a randomized controlled trial exploring the e ects of a novel antiseptic, po- lyhexanide biguanide (PHMB) on bacterial loads. PHMB added to tie-over dressings in full-thickness skin grafting did not decrease bacterial loads and paradoxically increased the incidence of SSIs in the intervention group.
In study III, we examined whether wound uids obtained from dermatosurgical wounds could pre- dict the occurrence of an SSI. Our results showed that the investigated biomarkers could indeed ser- ve as diagnostics for assessing wound healing.
In study IV, the aim of the study was to assess in- ter-observer agreement when assessing wound healing in dermatologic surgery. There was a bro- ad inter-observer variability in the diagnosis of an SSI illustrating the need for objective diagnostic methods that capture an actual SSI.
Ultimately, we provided new insights into SSIs in dermatologic surgery that can be useful in discove- ring methods to prevent these types of infections in the future.
Keywords: Surgical site infections (SSIs), derma- tologic surgery, full-thickness skin grafting, acute wounds, wound healing, microbiome, diagnostics, prevention, pathogenesis.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Award date||2019 Feb 1|
|Place of Publication||Lund|
|Publication status||Published - 2019|
Related research output
Research output: Contribution to journal › Debate/Note/Editorial
Research output: Contribution to journal › Article