Surgical stress response after colorectal resection.

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Surgical stress response after colorectal resection. / Andersson, Bodil; Ansari, Daniel; Nordén, Morgan; Nilsson, Johan; Andersson, Roland.

In: International Surgery, Vol. 98, No. 4, 2013, p. 292-299.

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TY - JOUR

T1 - Surgical stress response after colorectal resection.

AU - Andersson, Bodil

AU - Ansari, Daniel

AU - Nordén, Morgan

AU - Nilsson, Johan

AU - Andersson, Roland

PY - 2013

Y1 - 2013

N2 - Abstract The human body's response to surgery is correlated with the extent of tissue damage. The aim of the present study was to, over time, map out parameters concerning inflammation, metabolism, nutrition, breathing function, muscle strength, and well-being in elective colorectal surgery. Eighteen patients were prospectively included: colon resection (n = 9) and rectum resection/amputation (n = 9). Postoperative interleukin 10 (IL-10) rose more in the rectum surgery group on day 0 (P = 0.007) and day 3 (P = 0.025). Furthermore, significant differences between groups were detected regarding albumin, prealbumin, and total iron-binding capacity (TIBC). For albumin and TIBC, this difference was seen even on day 7. C-reactive protein, IL-6, IL-8, glucose, cortisol, insulin, pain, fatigue, nausea, grip strength, and forced expiratory volume in 1 second did not show any differences. No correlation was revealed between measured parameters and postoperative complications. Postoperative levels of IL-10, albumin, prealbumin, and TIBC may be used as determinants of surgical stress after colorectal surgery.

AB - Abstract The human body's response to surgery is correlated with the extent of tissue damage. The aim of the present study was to, over time, map out parameters concerning inflammation, metabolism, nutrition, breathing function, muscle strength, and well-being in elective colorectal surgery. Eighteen patients were prospectively included: colon resection (n = 9) and rectum resection/amputation (n = 9). Postoperative interleukin 10 (IL-10) rose more in the rectum surgery group on day 0 (P = 0.007) and day 3 (P = 0.025). Furthermore, significant differences between groups were detected regarding albumin, prealbumin, and total iron-binding capacity (TIBC). For albumin and TIBC, this difference was seen even on day 7. C-reactive protein, IL-6, IL-8, glucose, cortisol, insulin, pain, fatigue, nausea, grip strength, and forced expiratory volume in 1 second did not show any differences. No correlation was revealed between measured parameters and postoperative complications. Postoperative levels of IL-10, albumin, prealbumin, and TIBC may be used as determinants of surgical stress after colorectal surgery.

U2 - 10.9738/INTSURG-D-12-00009.1

DO - 10.9738/INTSURG-D-12-00009.1

M3 - Article

VL - 98

SP - 292

EP - 299

JO - International Surgery

JF - International Surgery

SN - 0020-8868

IS - 4

ER -