Swedish national guideline for prevention and treatment of neonatal hypoglycaemia in newborn infants with gestational age ≥35 weeks

Research output: Contribution to journalReview article


Aim: Postnatal hypoglycaemia in newborn infants remains an important clinical problem where prolonged periods of hypoglycaemia are associated with poor neurodevelopmental outcome. The aim was to develop an evidence-based national guideline with the purpose to optimise prevention, diagnosis and treatment of hypoglycaemia in newborn infants with a gestational age ≥35 + 0 weeks. Methods: A PubMed search-based literature review was used to find actual and applicable evidence for all incorporated recommendations. The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach was used for grading the evidence of the recommendations. Results: Recommendations for the prevention of neonatal hypoglycaemia were extended and updated, focusing on promotion of breastfeeding as one prevention strategy. Oral dextrose gel as a novel supplemental therapy was incorporated in the treatment protocol. A new threshold-based screening and treatment protocol presented as a flow chart was developed. Conclusion: An updated and evidence-based national guideline for screening and treatment of neonatal hypoglycaemia will support standardised regimes, which may prevent hypoglycaemia and the risk for hypoglycaemia-related long-term sequelae.


External organisations
  • Karolinska University Hospital
  • Södersjukhuset
  • Queen Silvia Children’s Hospital
  • Skåne University Hospital
  • Umeå University
  • Uppsala University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics


  • breastfeeding, dextrose gel, guideline, hypoglycaemia, newborn infant
Original languageEnglish
JournalActa Paediatrica, International Journal of Paediatrics
Publication statusE-pub ahead of print - 2019 Jul 27
Publication categoryResearch