Synaptic vesicle protein 2A as a potential biomarker in synaptopathies

Research output: Contribution to journalReview article

Abstract

Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.

Details

Authors
Organisations
External organisations
  • Sahlgrenska Academy
  • King's College London
  • University of Gothenburg
  • Federal University of Rio Grande do Sul
  • Pontifical Catholic University of Rio Grande do Sul
  • Sahlgrenska University Hospital
  • University College London
  • Uppsala University
  • Uppsala University Hospital
  • South London and Maudsley NHS Foundation Trust
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Biomarkers, Position emission tomography, SV2A, Synaptopathies
Original languageEnglish
Pages (from-to)34-42
JournalMolecular and Cellular Neuroscience
Volume97
Early online date2019
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes