Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
Research output: Contribution to journal › Review article
Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Molecular and Cellular Neuroscience|
|Early online date||2019|
|Publication status||Published - 2019|