Synergistic platelet inhibition between Omega-3 and acetylsalicylic acid dose titration; an observational study

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@article{d002174f0e274ad2968bb7a24a09f644,
title = "Synergistic platelet inhibition between Omega-3 and acetylsalicylic acid dose titration; an observational study",
abstract = "Background: Omega-3 and acetylsalicylic acid (ASA) are two widely used “over-the-counter” drugs. Previous researchhas shown multiple electrode aggregometry (MEA) can detect ASA and varying Omega-3 platelet inhibiting effects.Synergistic platelet inhibiting effects of ASA and Omega-3 have been found using other methods than MEA. The aimof this study was to investigate the antiplatelet effects of Omega-3, and ASA synergism with MEA.Methods: Ten healthy male volunteers ingested Omega-3 (1260mg/day) for 5 days. MEA was used to analyse plateletfunction before and after Omega-3 intake. Aggregation was initiated using three different agonists and measured asarea under the curve (AUC): adenosine diphosphate (ADP), thrombin receptor activating peptide (TRAP) andarachidonic acid (ASPI). Two concentrations of ASA were dose titrated ex vivo to 2 out of 3 ASPI test cells in order tomeasure synergism between Omega-3 and ASA.Results: Following 5 days Omega-3 intake, ADP, TRAP and ASPI AUC did not change significantly. In vitro ASA beforeOmega-3 intake, reduced ASPI AUC < 30 U, indicating a strong platelet inhibiting effect. Below this AUC level, the 5 daysOmega-3 intake increased ASPI-AUC with the ex vivo added low dose ASA (P = 0.02) and high dose ASA (P = 0.04).Conclusions: No synergism between ASA and Omega-3 was found using the MEA ASPI test. The surprising increase inASPI-AUC following Omega-3 intake and ex vivo ASA suggest that there are methodological issuses with the MEA ASPI test.",
keywords = "Acetylsalicylic acid, Coagulation, Omega-3",
author = "Harald Bagger and Mattias Hansson and Thomas Kander and Ulf Schott",
year = "2020",
month = jul,
day = "2",
doi = "10.1186/s12906-020-02990-9",
language = "English",
volume = "20",
pages = "1--9",
journal = "BMC Complementary Medicine and Therapies",
issn = "2662-7671",
publisher = "BioMed Central (BMC)",

}