Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids

Research output: Contribution to journalArticle

Abstract

The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.

Details

Authors
  • B Danieli
  • A Giardini
  • G Lesma
  • D Passarella
  • A Silvani
  • G Appendino
  • A Noncovich
  • G Fontana
  • E Bombardelli
  • Olov Sterner
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)327-345
JournalChemistry and Biodiversity
Volume1
Issue number2
Publication statusPublished - 2004
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)