Synthesis of decaline analogues of isovelleral

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Abstract

Decaline analogues of the bioactive fungal sesquiterpene (+)-isovelleral (1a), retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system, were prepared, and their cytotoxic and antimicrobial activities were compared with those of the natural product. While the two isomers (+/-)-2 and (+/-)-3 were as active as isovelleral (1a), the isomer (+/-)-4 was approximately 10 times less potent.

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  • Organic Chemistry
Original languageEnglish
Pages (from-to)984-989
JournalZeitschrift fuer Naturforschung. Section B: A Journal of Chemical Sciences
Volume60
Issue number9
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)