Synthesis of Imidates: TFA-Mediated Regioselective Amide Alkylation Using Meerwein's Reagent
Research output: Contribution to journal › Article
Regioselective O-alkylation of an amide to form the corresponding imidate is a common synthetic problem, often resulting in varying amounts of N-alkylation. Screening existing methods for converting amides to imidates gave inconsistent or irreproducible results, sometimes affording N-alkylamide as the major product. A simple and reliable protocol for amide O-alkylation with complete regioselectivity has been designed, and its scope and efficiency demonstrated on a number of substrates.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Number of pages||3|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 2016 Apr 15|