Synthesis of naproxen-imprinted polymer using Pickering emulsion polymerization

Research output: Contribution to journalArticle

Abstract

For the last decades, molecular imprinting is developing intensively, especially in the case of the application of new imprinting techniques. In this work, for the first time, a Pickering emulsion polymerization was used to synthesize the S-naproxen-imprinted polymer spheres following a noncovalent protocol. To enhance the knowledge about imprinting process using mentioned technique, thorough analysis of the synthesis process was performed. Optimization of polymerization conditions included the selection of functional monomer, cross-linking agent, type of porogen, surfactant, and the choice of appropriate amount of the template and porogen. Prepared materials were characterized using scanning electron microscopy and nitrogen adsorption. To study the binding properties, the sorption studies, including adsorption isotherms and competitive binding, were performed. Investigation of the effect of the functional monomer on the selective recognition of S-naproxen showed that the interactions between the template molecule and 4-vinylpyridine resulted in the best recognizing ability. Moreover, the synthesis with application of ethylene glycol dimethacrylae as a cross-linker, toluene as a porogen, and Tween 20 as an additional emulsion stabilizer gave the most desired result. The optimal ratio of the porogen to monomers mixture was 0.1, due to the fact that the increase of the porogen volume resulted in the significant increase of nonspecific uptake. In addition, the tenfold molar excess of functional monomer relative to the template turned out to be optimal. Subsequent binding studies demonstrated that the material synthesized using optimized polymerization conditions consists of imprinted sites that are sensitive for the S-naproxen.

Details

Authors
  • Małgorzata Kujawska
  • Tongchang Zhou
  • Andrzej W. Trochimczuk
  • Lei Ye
Organisations
External organisations
  • Wrocław University of Science and Technology
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Polymer Chemistry
  • Biochemistry and Molecular Biology

Keywords

  • MIP, Pickering emulsion, Triton X-100, Tween 20
Original languageEnglish
Pages (from-to)e2626
JournalJournal of Molecular Recognition
Volume31
Issue number3
Early online date2017 Mar 21
Publication statusPublished - 2018 Mar
Publication categoryResearch
Peer-reviewedYes